Director, Tanz Centre for Research in Neurodegenerative Diseases.
Professor, Division of Neurology, Department of Medicine, University of Toronto. Hospital Affiliation: University Health Network – Toronto Western Hospital.
Research Interests
- The mapping, cloning and/or functional characterization of genes associated with human neurodegenerative diseases with the main focus on Alzheimer’s Disease;
- Identification and functional characterization of components of the presenilin complex;
- Converging mechanisms in neurodegenerative diseases and cancers.
Selected most recent peer-reviewed publications (in chronological order)
Kennedy JL, Farrer LA, Andreasen NC, Mayeux R, St George-Hyslop P. (2003) The genetics of adult-onset neuropsychiatric disease: complexities and conundra? Science 302:822-826.
Lincoln S, Wiley J, Lynch T, Langston JW, Chen R, Lang A, Rogaeva E, Sa DS, Munhoz RP, Harris J, Marder K, Klein C, Bisceglio G, Hussey J, West A, Hulihan M, Hardy J, Farrer M. “Parkin-proven disease: Common founders but divergent phenotypes”, Neurology 2003 May 27; 60(10):1605-10.
Rogaeva E, Bergeron C, Sato C, Moliaka I, Kawarai T, Toulina A, Song Y-Q, Kolesnikova T, Orlacchio A, Bernardi G, St George-Hyslop P. H. “PS1 Alzheimer’s Disease family with spastic paraplegia: the search for a gene-modifier” Neurology 2003 Oct 14;61(7):1005-7.
Kleiner-Fisman G, Rogaeva E, Halliday W, Houle S, Kawarai T, Sato C, Medeiros H., St George-Hyslop P, Lang A. “Benign Hereditary Chorea: Clinical, Genetic and Pathological Findings” Annals of Neurology 2003 Aug; 54(2):244-7.
Hague S, Rogaeva E, Hernandez D, Gulick C, Singleton A, Hanson M, Johnson J, Weiser R, Gallardo M, Ravina B, Gwinn-Hardy K, Crawley A, St George-Hyslop PH, Lang AE, Heutink P, Bonifati V, Hardy J and Singleton A, “Identification of a compound heterozygous mutation in DJ-1 causing early-onset Parkinson’s disease” Annals of Neurology 2003 Aug, 54 (2):271-274.
Peltekova VD, Wintle RF, Rubin LA, Amos CI, Huang Q, Gu X, Newman B, Van Oene M, Cescon D, Cohen Z, Griffiths AM , Steinhart H, St George-Hyslop PH, Siminovitch KA. Mutations of the OCTN1 and OCTN2 cation transporter genes are associated with Crohn’s disease. Nature Genetics 6:471-475, 2004.
A.Petit, T Kawarai, E Paitel1, N Sanjo, M Maj, M Scheid. F Chen, Y Gu, H Hasegawa, S. Salehi-Rad, L Wang, E Rogaeva, P Fraser, B Robinson, P St George-Hyslop, A Tandon. “Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson’s Disease-related mutations”. J Biol Chem. 2005 Aug 2; [Epub ahead of print].
Pardossi-Piquard R, Petit A, Kawarai T, Sunyach C, Alves da Costa C, Vincent B, Ring S, D’Adamio L, Shen J, Muller U, St George Hyslop P, Checler F. Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP Neuron. 2005 May 19;46(4):541-54.
Paisán-Ruίz C, Lang AE, Kawarai T, Sato C, Salehi-Rad S, Kleiner Fisman G, Al-Khairallah T, St George-Hyslop P, Singleton A, Rogaeva E “LRRK2 gene in Parkinson’s Disease: mutation analysis and case control association study”; Neurology 2005 Sep 13;65(5):696-700.
McLaurin J, Kierstead ME, Brown ME, Hawkes CA, Lambermon MH, Phinney AL, Darabie AA, Cousins JE, French JE, Lan MF, Chen F, Wong SS, Mount HT, Fraser PE, Westaway D, St George-Hyslop P. Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model Nat Med. 2006 Jul;12(7):801-8.
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.Nature. 2006 Apr 27;440(7088):1208-12.
Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P.The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.Nat Genet. 2007 Feb;39(2):168-77. Epub 2007 Jan 14.
can this help with my mother who has fronto temporal dementia
The research being conducted at the CRND impacts many areas of neurodegenerative disease, as there are similarities between Alzheimer’s and other forms of dementia. However the CRND would not be a direct source of assistance to patients and you need to work with your local family medical team. We hope this helps, and that someday Dr. St Goerge Hyslop and his team will indeed find that cure, or a way to delay the onset of neruodegenerative disease.